Starting out as a fighter boxing the champion boxer dogs, the dog with the stage name, Muscle Dog, earned his living by winning fights. He fought as a way to raise money for muscular dystrophy, but after retirement, he decided that he wanted to contribute more to the economy.
Suddenly, two wacky Muscle Dog fanboys, Zony, the roadrunner, and Zach, the tiger, came to him to offer him a job. They are obsessed with boxing and are quite nerdy about it. They claim to be his biggest fans, but they coincidentally also work for an investigation service, but they are slackers. They work for Fredrick, who leads a high ranked investigation team. He is tracking a man named James Mad, who he suspects to be involved in casino robberies and theft of military hardware. He is hesitant about Muscle Dog joining the team, but when it is realized that he once knew their criminal suspect, Fredrick decides to test his abilities.
Meanwhile, mad scientist, Dr. Mad, founder of his corporation, Mad Machines, introduced new hardware to the world. He is attempting to pass an agreement for his creations and for his ingenious thinking to be used for the government and military by faking his ID. His idea is to use his manipulative talents to convince the people to love him and support his new plans. What people don't realize yet is that Dr. Mad has been faking everything. He has no experience in government or robot science; he is just a robber with a lot of knowledge in those fields. And the products he wants to promote have a mind-controlling operation on them. His ultimate plan is to force the people to vote for him to become president for all of eternity.